These lesions occur 23 times more frequently in mandible than in maxilla 1. Central giant cell granuloma cgcg is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of. Central giant cell granuloma of the posterior maxilla. We describe a case of central giant cell granuloma arising from the anterior maxilla to highlight to the general dental practitioner the importance of histopathology in the diagnosis of this enigmatic lesion. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. But the term reparative is obsolete, as cgcg causes the destruction of involved bones.
Central giant cell granuloma cgcg accounts for 17% of all benign lesions of the head and neck region. Central giant cell granuloma cgcg is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone1. Case report central giant cell granuloma of posterior. The case reported here resembled a wide variety of conditions. Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior.
We present a case of an aggressive central giant cell granuloma cgcg in a six yearold female. Though a benign tumor, central giant cell granuloma may be a locally destructive in some cases and if left untreated may cause facial asymmetry thus compromising the quality of life of the individual. Pdf central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown. Central giant cell granuloma is a rare lesion of the head and neck region. It occurs most commonly on the mandible than in maxilla. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examination but was histopathologically diagnosed as cgcg. These lesions occur 23 times more frequently in mandible than in maxilla. Central giant cell granuloma cgcg is a benign bone lesion which can be locally aggressive or may be asymptomatic in nature. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. Central giantcell granulomas are more common in the anterior mandible, often crossing the. Radiotherapy for recurrent central giant cell granuloma. A central giant cell granuloma in posterior part of maxillaa. It occurs most commonly in mandible, but can also occur in maxilla.
Central giant cell granuloma of the anterior maxilla. Central giant cell granuloma of the mandible american. Giant cell granuloma an overview sciencedirect topics. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and ra. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examination but was.
Giant cell central granuloma gccg is an uncommon pseudotumor of the maxilla. Intralesional steroid treatment of central giant cell. Aggressive variant of central giant cell granuloma. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature. It is twice as common in females and is more likely to occur before age 30. Central giant cell granuloma is a non neoplastic proliferation of unknown etiology. Jun 19, 2018 this peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. Central giant cell granuloma cgcg is a benign, proliferative, intraosseous and nonodontogenic lesion of unknown etiology. Free flap surgery in the pediatric population has gained widespread acceptance regarding its technical utility and reliability.
Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws. Central giant cell granuloma, swellings of anterior maxilla. Gcg, or rgcg is an uncommon benign bony lesion located in the mandible and maxilla1. The mass involves the anterior wall of the maxilla, causing asymmetry of the right hard palate. Case report giant cell tumor of the maxilla in an 8 year. The central giant cell lesion of the jaw is a rare benign tumour with an unknown aetiology accounting for up to 7% of tumours in the mandible lower jaw and the maxilla upper jaw. Although it is a benign disease process, it can also be locally destructive. Central giantcell granuloma cgcg is a localised benign condition of the jaws. Case report central giant cell granuloma of posterior maxilla.
Central giant cell granuloma of the anterior maxilla core. Surgery is the most accepted method of treating the condition. The term giant cell reparative granuloma gcrg was first used by jaffe in 1953, to distinguish these lesions from giant cell tumor of long bones. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible expansion of.
An aggressive central giant cell granuloma treated successfully by. The neoplastic status of the central giant cell granuloma of the jaws remains an unsolved contro versy in anatomic pathology. Central giant cell granuloma is an uncommon benign proliferative lesion occurring more commonly in the anterior mandible. Case report giant cell tumor of the maxilla in an 8 year old boy sabhlok s1, shaikh mi2, tripathy r3, mishra s4. Pdf central giant cell granuloma of the posterior maxilla. An aggressive central giant cell granuloma in a pediatric. Central giant cell granuloma of the mandible in children with. The case reported here resembled a wide variety of conditions that led to a. Aggressive central giant cell granuloma of the mandible, a. First expression of primary hyperparathyroidism deepanshugulati, 1 vishalbansal, 1 prajeshdubey, 1 sanjaypandey, 2 andabhinavagrawal 3 department of oral and maxillofacial surgery, subharti dental college, meerut, india department of general surgery, subharti medical college, meerut, india. It is a nonodontogenic tumor never seen in any other bone of the skeleton. It is more often found in the mandible rather than the maxilla, in either anterior or posterior areas.
It accounts for 7% benign maxillary tumors, and females are predominantly affected in 23ofcases before age 20years 1. It may become aggressive leading to expansion and perforation of the cortex. Giant cell granuloma is a rare bony lesion in the head and neck region. Surgery is the traditional and still the most accepted treatment for giant cell granuloma. To the best of our knowledge, the present case is the first report of recurrent. Recurrent central giant cell granuloma in the mandible. In 1953, jaffe described it as reparative granuloma of jaw bones 1. Tumorinduced osteomalaciarickets is a rare paraneoplastic disorder associated with a tumorproducing fibroblast growth factor 23 fgf23. Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs almost exclusively in the mandible, although. An aggressive central giant cell granuloma in a pediatric patient. It most commonly affects maxilla followed by the mandible. A central giant cell granuloma in posterior part of maxillaa case. Central giant cell granuloma cgcg is a localised benign condition of the jaws.
On biopsy, the mass in our case turned out to be a giant cell granuloma, formally called giant cell reparative granuloma, which is a distinct entity from a giant cell tumor and in fact is not considered a tumor, but a reactive process, originally thought to be a response to trauma. The case report is of a 30 year old male, who complained of a slowly expanding swelling in the maxilla in the left premolar region. Case report giant cell tumor of the maxilla in an 8 year old boy. Central giantcell is a benign lesion that predominantly involves the bone of the mandible and maxilla with a wide varia. It appears only on the gingiva or on an edentulous alveolar ridge. Central giant cell granuloma is a nonneoplastic proliferative lesion of unknown etiology. Aug 15, 2008 central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology. Aggressive and nonaggressive form, central giant cell granuloma, conventional surgery, differential diagnosis, maxilla, radical surgery. The true nature of these lesions is unknown but, as they are invariably destructive, the term reparative giant cell granuloma would. Aggressive variant of central giant cell granuloma austin. This peripheral giant cell granuloma involved the maxillary gingiva associated with an erupting central incisor of a 6yearold girl. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio.
The case described here involved maxilla which was treated with surgical excision. A central giant cell granuloma in posterior part of. Pdf central giant cell granuloma of the anterior maxilla. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on.
Giant cell tumor of the maxilla in an 8 year old boy. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing central giant cell granuloma in anterior maxilla shwetang goswami1, haripriya2, yashwanth yadav3, ram mohan4 abstract. Giant cell granuloma, intralesional injection, microvascular free flap, fibula. Central giant cell granuloma cgcg is an uncommon, benign, proliferative, and nonodontogenic lesion whose etiology is not defined. Jaffe hl 1953 giantcell reparative granuloma, traumatic bone cyst and. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Central giant cell granuloma cgcg is an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of hemorrhage, aggregations of multinucleated giant cells and occasionally trabeculae of woven bone. Central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Pdf central giant cell granuloma cgcg formerly called giant cell reparative granuloma is a nonneoplastic proliferative lesion of unknown. Cgcg accounts for less than 7 % of all benign lesions of mandible and maxilla. Tumorinduced rickets in a child with a central giant cell. Thought to represent a reparative response to intrabony haemorrhage and inflammation, cgcg was once regarded as a reactive lesion. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown. Traditional treatment has been local curettage, although aggressive subtypes.
Central giant cell granuloma involving mandible a report. The central giant cell granuloma is an uncommon lesion only seen in the toothbearing regions of the jaws, most commonly in the mandible and typically in the second and third decades. Cgcg, as described by jaffe in 1953 is an idiopathic nonneoplastic proliferative lesion. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing a rare presentation.
Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of unknown etiology. Most mandibular lesions occur anterior to first molars and often cross the midline. Hooman e, yazdani j, pourshahidi s, esmaeli f, taghavi zenouz a, mehdipour m. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically.
It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. First expression of primary hyperparathyroidism deepanshugulati, 1 vishalbansal, 1 prajeshdubey, 1 sanjaypandey, 2 andabhinavagrawal 3 department of oral and maxillofacial. Central giant cell granuloma cgcg formerly called giant cell reparative granuloma is a nonneoplastic proliferative lesion of unknown etiology. It often arises in the maxilla followed by mandible and affects children and young adults. It was jaffe who first introduced the term central giant cell reparative granuloma to distinguish this lesion from the giant cell tumor of long bones. Mar 21, 2012 central giant cell granuloma is a non neoplastic proliferation of unknown etiology. Whitaker sb, waldron ca 1993 central giant cell lesions of the jaws. As mentioned earlier, it can be aggressive or nonaggressive. There is limited characterization of this lesion by cone beam ct, but the appearance is suggestive of a benign neoplasm solid or cyst. The term reparative giant cell granuloma was at one time widely. Cgcg accounts for less than 7% of all benign lesions of mandible and maxilla. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology.
It occurs most commonly in the mandible than in the maxilla. Giant cell granuloma is an uncommon bony lesion in the head and neck region, most commonly affecting the maxilla and mandible. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. Central giant cell granuloma of the maxilla bmj case reports. Mar 21, 2012 central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. The prevalence of the peripheral giantcell granuloma is highest around 50 60 years of age. We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma cgcg with high serum levels of fgf23, a hormone associated with decreased phosphate resorption. The referring doctor had suggested a diagnosis of eruption cyst. Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al.
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